CHLOROAMIDATION OF ALKENES USING SODIUM HYPOCHLORITE PENTAHYDRATE AND ITS APPLICATION TO SYNTHESIS OF AZIRIDINES

摘要

The reaction of alkenes with sodium hypochlorite pentahydrate（NaOCl-5H20)and phosphoric acid（H3PO4)in nitrile solvents resulted in a chloroamidation reaction,producing α-chloroamide derivatives in good yields without the use of a transition metal catalyst（up to 90).N-Pivalazirizines were readily obtained from the resulting a-chloroamide derivatives when they were reacted with lithium hexamethyldisilazide（LiHMDS).