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Epithelioid hemangioendothelioma of sphenoid bone: A case report of an unusual case

机译:蝶骨上皮样血管内皮瘤:一例病例报道

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A 42-year-old woman presented with diplopia and headache of 3 months duration. She was found to have ptosis and decreased visual acuity of right eye. Computed tomography (CT) scan and magnetic resonance imaging (MRI) showed a 2.8 cm-sized sellar lesion with areas of mineralization [Figure 1]. Endocrine evaluation was normal. Surgical debulking of the tumor was done through frontotemporal craniotomy. The tumor was seen involving the sphenoidal sinus, sphenoid bone, and clivus. Histological evaluation revealed a malignant tumor composed of irregular oval to pleomorphic cells of epithelioid morphology admixed with elongated ovoid tumor cells arranged in sheets and f ocally lining the slit-like vascular spaces with a variably hyalinized myxochondromatous stroma in the background [Figure 2]. The tumor cells showed eosinophilic cytoplasm with cytoplasmic vacuoles containing an occasional erythrocyte in few cells [Figure 2d]. Scattered foci of metaplastic calcification were seen. Mitotic activity was very occasional and no necrosis seen.
机译:一名42岁妇女出现复视和持续3个月的头痛。发现她患有上睑下垂,右眼视力下降。计算机断层扫描(CT)扫描和磁共振成像(MRI)显示了一个2.8 cm大小的鞍状病变,并有矿化区域[图1]。内分泌评估正常。通过额颞开颅手术对肿瘤进行手术切除。看到肿瘤累及蝶窦,蝶骨和锁骨。组织学评估显示,恶性肿瘤由上皮样形态的不规则椭圆形到多形细胞,与排列成片状的细长卵形肿瘤细胞混合而成,并在背景上以可变的透明化的线粒体基质衬在狭缝状血管空间内[图2]。肿瘤细胞显示嗜酸性细胞质,少数细胞中有偶有红细胞的细胞质液泡[图2d]。可见散在的化石钙化灶。有丝分裂活动非常少见,没有坏死。

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