Considerations on methylmercury (MeHg) treatments in in vitro studies

摘要

It is quite often that as researchers performing in vitro studies we are asked by reviewers of a manuscript or a grant proposal "what is the physiological relevance of the concentrations you use?" Indeed, it is incumbent upon the author to provide and prove the physiological relevance of their studied compound. Having gone through a myriad of these scenarios, I take the liberty to provide you with a justification for the in vitro concentrations of one of my favorite compounds, methylmercury. I encourage others with their preferred compound to apply the same exercise. To avoid future criticisms, please feel free to incorporate this description into you grant or paper.