Chlorakuamminium: A new (Chlorinated) indolealkaloid of the akuamma skeleton from the seed of Hunteria umbellata (K.Schum)

摘要

Chemical investigations into an aqueous fraction of a crude methanolic extract of a Nigerian collection of the seeds of the indolealkaloid-rich plant, Hunteria umbellata, has yielded a new chlorinated indolealkaloid chlorakuamminium. Chloraquamminium is the N-chloromethyl analogue of the akuamma indolealkaloid, akuammine. It was isolated by HPLC and characterized largely by 2D NMR techniques. The covalently bonded chlorine in chlorakuamminum is not only new to the akuamma skeleton;; it is actually a spectacular phenomenon in higher terrestrial plant secondary metabolism.