Forging a proteasome alpha-ring with dedicated proteasome chaperones

摘要

Assembly of the 34- subunit, 2.5 megadalton 26S proteasome starts with formation of the seven-membered alpha-ring. A set of newly identified proteasome chaperones serves as a clamp to seal alpha-rings with the correct composition. By regulating the efficiency and outcome of this crucial step in proteasome biogenesis, these dedicated proteasome chaperones apparently partake in the stress response and in adaptation to intracellular proteolysis needs.