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首页> 外文期刊>Nature structural & molecular biology >Forging a proteasome alpha-ring with dedicated proteasome chaperones
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Forging a proteasome alpha-ring with dedicated proteasome chaperones

机译:用专用的蛋白酶伴侣来锻造蛋白酶体的α-环

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摘要

Assembly of the 34- subunit, 2.5 megadalton 26S proteasome starts with formation of the seven-membered alpha-ring. A set of newly identified proteasome chaperones serves as a clamp to seal alpha-rings with the correct composition. By regulating the efficiency and outcome of this crucial step in proteasome biogenesis, these dedicated proteasome chaperones apparently partake in the stress response and in adaptation to intracellular proteolysis needs.
机译:34亚单位的2.5兆道尔顿26S蛋白酶体的组装始于七元α环的形成。一组新近鉴定的蛋白酶体分子伴侣可作为夹子,以正确的成分密封α环。通过调节这一重要步骤在蛋白酶体生物发生中的效率和结果,这些专用的蛋白酶体伴侣显然参与了应激反应并适应了细胞内蛋白水解的需要。

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