Two new triterpenoid glycosides from the stems of Camellia oleifera Abel

摘要

Two new oleanane-type triterpenoid glycosides, 3-O--D-xylopyranosyl-(12)--L-arabinopyranosyl-(13)-[-D-glucuronopyranosyl-(12)]--D-glucuronopyranosyl-22-angeloyloxyolean-12-ene-15,16,28-triol(1) and 3-O--D-xylopyranosyl-(12)--L-arabinopyranosyl-(13)-[-D-glucuronopyranosyl-(12)]--D-glucuronopyranosyl-21-acetyl-22-angeloyloxyolean-12-ene-16,28-diol (2) were isolated from the stems of Camellia oleifera Abel. Their structures were elucidated by means of spectroscopic methods and chemical evidence. The cytotoxic activities of compounds 1-2 were evaluated against five human tumour cell lines (HCT-8, BGC-823, A5049, and A2780). Compounds 1-2 showed cytotoxic activity against five human cancer cell lines, with IC50 values ranging from 3.15 to 7.32 mu M.