Cell signalling: Putting the brakes on sonic hedgehog.

摘要

The organization of cellular differentiation during development requires the sensing of graded morphogen signals, such as sonic hedgehog (SHH). A recent study by Mukhopadhyay et al. describes a novel signalling receptor pathway in which the G protein-coupled receptor (CPCR) GPR161 mediates the basal repression of SHH-dependent gene transcription and can be downregulated when SHH is activated.