Chronic kidney disease: Blood-pressure targets in chronic kidney disease.

摘要

The recently reported results of the extended follow-up of the African American Study of Kidney Disease and Hypertension (AASK) cohort1 address the ongoing controversy regarding the optimal blood-pressure target (<130/90mmHg) recommended by current guidelines for patients with chronic kidney disease (CKD). Although observational data from multiple studies show positive and graded associations between blood pressure and risk of CKD progression, prospective randomized controlled trials in patients with CKD have failed to directly demonstrate that blood-pressure targets < 130/90 mmHg further reduce CKD progression.