Atypical Chemokine Receptors in Renal Inflammation

摘要

Chemokines are structurally related proteins which form a large family of chemotactic cytokines. They provide a general communication system for cells and regulate lymphocyte migration. These proteins orchestrate the formation of microenvironments in lymphoid tissue, promote lymphoid organogenesis and help foster vascular and lymphatic an-giogenesis. In addition to the classical G protein-coupled chemokine receptors, many chemokines also bind to a family of nonsignaling proteins, now called interceptors (chemo-kine-internalizing proteins). Here we summarize recent data on the role of interceptors in chemokine biology with a focusOn renal inflammation.