ACE gene I/D polymorphism and the presence of renal failure or hypertension in autosomal dominant polycystic kidney disease (ADPKD).

摘要

Epidemiological data have suggested that interactions between multiple genetic and environmental factors are involved in the process of progressive renal damage in the course of various kidney diseases, including autosomal polycystic kidney disease [1-4]. Recently, we read with interest the results of a meta-analysis of studies examining the association between angiotensin I-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and the presence of end-stage renal disease (ESRD) in patients with ADPKD . Based on the analysis of combined data from 13 reports, Pereira et al. found no proof for the involvement of ACE gene I/D marker in the development of ESRD. or hypertension in ADPKD patients.