DNA methylation secures CD4(+) and CD8(+) T cell lineage borders

Feng Yongqiang; Rudensky Alexander Y.

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DNA methylation secures CD4(+) and CD8(+) T cell lineage borders

机译：DNA甲基化可确保CD4（+）和CD8（+）T细胞谱系边界

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Dynamic control of DNA methylation in the Cd4 locus serves an important role in reinforcing the binary fate stability of helper and cytotoxic T cells.

机译：Cd4基因座中DNA甲基化的动态控制在增强辅助T细胞和细胞毒性T细胞的二元命运稳定性方面起着重要作用。

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《Nature immunology》 |2015年第7期|共4页
作者
Feng Yongqiang; Rudensky Alexander Y.;
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正文语种 eng
中图分类医学免疫学;
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1. DNA methylation secures CD4(+) and CD8(+) T cell lineage borders [J] . Feng Yongqiang, Rudensky Alexander Y. Nature immunology . 2015,第7期

机译：DNA甲基化可确保CD4（+）和CD8（+）T细胞谱系边界
2. The DNA methylation signature of human TCR alpha beta+CD4-CD8-double negative T cells reveals CG demethylation and a unique epigenetic architecture permissive to a broad stimulatory immune response [J] . Renauer Paul A., Coit Patrick, Sawalha Amr H. Clinical immunology: The official journal of the Clinical Immunology Society . 2015,第1期

机译：人类TCRαβ+ CD4-CD8-双阴性T细胞的DNA甲基化特征揭示了CG脱甲基化和独特的表观遗传结构，可实现广泛的刺激性免疫应答
3. Peripheral blood extrathymic CD4(+)CD8(+) T cells with high cytotoxic activity are from the same lineage as CD4(+)CD8(-) T cells in cynomolgus monkeys. [J] . Nam K, Akari H, Terao K, International immunology. . 2000,第7期

机译：具有高细胞毒性活性的外周血胸腺CD4（+）CD8（+）T细胞与食蟹猴中的CD4（+）CD8（-）T细胞来自同一谱系。
4. IMMUNIZATION OF DENDRITIC CELLS PULSED WITH PRRS VIRUS GP5 PROTEIN INDUCES CD4+ BUT NOT CD8+ T CELLS [C] . Nguyen-Dinh Quat, Jeongran Min, Jiwon Han, Congress ofthe International Pig Veterinary Society . 2008

机译：用PRRS病毒GP5蛋白脉冲树突细胞的免疫诱导CD4 +但不是CD8 + T细胞
5. The Regulation of Cd4 in T Cells: Lineage Commitment and Heritable Silencing of Cd4 Expression in CD8 + Cytotoxic T Cells [D] . Ng, Charles. 2019

机译：T细胞中Cd4的调节：CD8 +细胞毒性T细胞中Cd4表达的谱系承诺和遗传沉默
6. The DNA methylation signature of human TCRαβ+CD4−CD8− double negative T cells reveals CG demethylation and a unique epigenetic architecture permissive to a broad stimulatory immune response [O] . Paul A. Renauer, Patrick Coit, Amr H. Sawalha -1

机译：人TCRαβ+ CD4-CD8-双阴性T细胞的DNA甲基化特征揭示了CG脱甲基化和独特的表观遗传学结构可实现广泛的刺激性免疫应答
7. Genome-Wide DNA Methylation Analysis in Systemic Sclerosis Reveals Hypomethylation of IFN-Associated Genes in CD4+ and CD8+ T Cells [O] . Weifeng Ding, Weilin Pu, Lei Wang, 2018

机译：全身硬化中的基因组DNA甲基化分析显示了CD4 +和CD8 + T细胞中IFN相关基因的低甲基化

DNA methylation secures CD4(+) and CD8(+) T cell lineage borders

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