ENDOCRINE PANCREAS MORPHOGENESIS OF BUFO BUFO DURING METAMORPHOSIS

摘要

Anatomical modifications, immunohistochemistry and cytology of the pancreas during metamorphosis of Bufo bufo were studied. Endocrine insulin-producing cells appear at the beginning of metamorphosis, cells producing glucagon, somatostatin (14) and pancreatic polypeptide (PP) appear together, a few days later. Extensive anatomical remodelling, determined by programmed cell death and mitosis occurred during metamorphic climax and later, until the adult structure is attained.