ENDOGENOUS ANGIOTENSINS, ANGIOTENSIN II COMPETITIVE BINDING INHIBITORS AND CONVERTING ENZYME INHIBITOR IN ELASMOBRANCH FISH

摘要

This study demonstrates the potent vasopressor activity of homologous dogfish angiotensin (A)I and II. The AII competitive binding inhibitors [Sar(1)-Val(5)-Ala(8)]-AII and [Sar(1)-Ile(8)]-AII did not inhibit the presser action of dogfish AIT but the converting enzyme inhibitor captopril effectively blocked conversion of AI to AII.