Oxidative Stress Induced Biochemical Alterations Due to Novel InTiO Nanoparticles Exposure

摘要

In the present study, we have synthesized, characterised indium titanium oxide nanoparticles (InTiO NPs) by sequential manner using FTIR, XRD and TEM-EDS methods and analysed its toxic nature by investigating biochemical, antioxidants and histopathology in albino rats. TEM analysis revealed that the average size of the InTiO is 58.25 nm. Oral administration (50 mg/Kg) of InTiO NPs to albino rats showed significant alterations in serum glutamate oxaloacetate transaminase (SGOT), glutamate private transaminase (SGPT), alkaline phosphatise (ALP), total and direct bilirubin (TB and DB), antioxidants glutathione (GSH), catalase (CAT), glutathione peroxidise (GPx), superoxide dismutase (SOD), lipid per oxidation (LPO) and total protein (TP) status relative to control groups. InTiO NPs exposed liver tissues showed marked structural alterations such as necrosis, degeneration of hepatocytes. The results of the present investigation indicate that the mechanism for InTiO NPs induced toxicity includes alteration in biochemical, antioxidants and histopathology might have been resulted from oxidative stress caused by the nanoparticles.