Ushikulide C, a New Immunosuppressant from Streptomyces sp. IUK-102

摘要

Ushikulide C (1), a new immunosuppressant, was isolated from the culture broth of Streptomyces sp. IUK-102. The structure of 1 is a new 22-membered macrolide that is related to ushikulides A (2) and B (3). The immunosuppressive activity of 1 on murine splenocyte proliferation in vitro was comparable with those of 2 and 3.