Terpenoids from Cichorium intybus

摘要

A new sesquiterpenoid, 1α,5α-epoxy-4α-hydroxyl-4β, 10β-dimethyl-7αH,10αH-guaia-11(13)-en-12-oic acid (1), and four known compounds, lactucin (2), 1β-hydroxy-7αH,8,11βH-eudesm-3- en-8,12-olide (3), 13,14-seco-stigma 9(11),14(15)-dien-3α-ol (4), and bacosterol-3-O-β-D-glucopyranoside (5) were isolated from Cichorium intybus L. Their structures were determined on the basis of detailed analysis of their 1D- and 2D-NMR spectroscopic and mass spectrometric data. Compounds 2 and 4 showed strong activities against the A2780 cell line with IC _(50) values of 1.81 and 0.07 μM, respectively.