Isolation of a New Anti-inflammatory 20,21,22,23,24,25,26,27-Octanorcucurbitacin-type Triterpene from Ibervillea sonorae

摘要

A new cucurbitane-type triterpene, 20, 21, 22, 23, 24, 25, 26,27-octanorcucurbita-5-ene-3, 11,16-trione (1), named kinoin D, was isolated from the roots of the medicinal plant Ibervillea sonorae, (wereque). The structure of 1 was established on the basis of extensive NMR and MS studies. In addition, the known kinoins B (3) and C (5) were isolated, as were 16α-20,25-trihydroxy-3α-(2-O-α-L-rhamnopyranosiyl-D-glucopyranosyloxy)-(10α)-cucurbit-5-en-11,22-dione (6), (22S)-16α,22-diacetoxy-20,25-dihydroxy-3α-[3,4,6-tri-O-acetyl-2-O-(2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl)-β-glucopyranosyl]-(10α)-cucurbita-5,23t- dien-11-one (7) and 16a-acetoxy-20,25-dihydroxy-3α-[3,4,6-tri-O-acetyl-2-O-(2,3,4,-tri-O-acetyl-α-L-rhamnopyranosyl)-β-D-glucopyranosyl]-(10α)-cucurbita-5-ene-11,22-dione (8). Compound 1 exhibited anti-inflammatory activity in TPA-Induced edema in mice.