Cytotoxic Aporphines from Artabotrys crassifolius

摘要

Artabotrys crassifolius Hook. f. & Thomson is a medicinal plant used in Malaysia. The cytotoxic effects of the hexane, chloroform and ethanol extracts of the leaves and bark were examined in vitro against MCF-7, MDA-468 and HCT-116 cells. The chloroform extract of the bark inhibited the growth of all cell lines with GI(50) values ranging from 4.2 mu g/mL to 9.4 mu g/mL. Silica gel column chromatography of this extract yielded artabotrine, liridine, atherospermidine and lysicamine. Artabotrine and lysicamine inhibited the growth of HCT-116 and MCF-7 cells with GI(50) values ranging from 3.3 mu M to 3.9 mu M. These alkaloids were not toxic to human embryonic kidney cells (HEK297) up to a concentration of 50 mu g/mL.