N-Demethylaaptanone, A new Congener of Aaptamine Alkaloids from the Vietnamese Marine Sponge Aaptos aaptos

摘要

A new compound, N-demethylaaptanone (5), having an oxygenated 1,6-naphthyridine core, has been isolated from the Vietnamese marine sponge Aaptos aaptos, along with the known metabolites, aaptamine (1), isoaaptamine (2), 9-demethylaaptamine (3), and aaptanone (4). The structure of N-demethylaaptanone was determined as 9-hydroxy-8-methoxy-4H-benzo[de][1,6]-naphthyridine-5,6-dione from spectroscopic data.