Phorbol esters with Wnt signal-augmenting effects isolated from Excoecaria indica

Yamaguchi T.; Toume K.; Arai M.A.; Ahmed F.; Sadhu S.K.; Ishibashi M.

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Phorbol esters with Wnt signal-augmenting effects isolated from Excoecaria indica

机译：Ex虫提取物中具有Wnt信号增强作用的佛波酯

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A screening of natural products using a luciferase assay targeting the Wnt signaling pathway was carried out, and the bioassay-guided fractionation of Excoecaria indica (Euphorbiaceae) collected from Bangladesh afforded three phorbol esters (1 - 3). These compounds exhibited Wnt signal-augmenting effects with 1 causing a 25-fold increase in TCF/β-catenin (TOP) transcriptional activity at 95 nM.

机译：使用针对Wnt信号通路的萤光素酶测定法对天然产物进行了筛选，从孟加拉国收集的印度Excoecaria indica（Euphorbiaceae）的生物测定法指导分馏提供了三种佛波醇酯（1-3）。这些化合物显示Wnt信号增强效应，其中1引起95 nM时TCF /β-catenin（TOP）转录活性增加25倍。

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《Natural product communications》 |2012年第4期|共3页
作者
Yamaguchi T.; Toume K.; Arai M.A.; Ahmed F.; Sadhu S.K.; Ishibashi M.;
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正文语种 eng
中图分类自然科学总论;
关键词
Diterpenoid; Euphorbiaceae; Wnt signal;

机译：二萜;大戟科;Wnt信号;

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专利

1. Phorbol esters with Wnt signal-augmenting effects isolated from Excoecaria indica [J] . Yamaguchi T., Toume K., Arai M.A., Natural product communications . 2012,第4期

机译：Ex虫提取物中具有Wnt信号增强作用的佛波酯
2. Dose-response Effects of Phorbol Esters Isolated from Jatropha Meal on Rumen Microbial Activities [J] . Ehsan Oskoueian, Norhani Abdullah, Wan Zuhainis Saad, Asian journal of animal and veterinary advances . 2014,第1期

机译：麻疯树粕中的佛波酯对瘤胃微生物活性的剂量效应
3. Different effects of phorbol ester on angiotensin II- and stable GTP analogue-induced activation of polyphosphoinositide phosphodiesterase in membranes isolated from rat renal mesangial cells [J] . C Bauer, J Pfeilschifter The biochemical journal . 1987,第1期

机译：佛波酯对大鼠肾系膜细胞分离膜中血管紧张素II和稳定GTP类似物诱导的多磷酸肌醇磷酸二酯酶活化的不同作用
4. Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-##B and AP-1 [C] . Young-Joon Surh, Seong Su Han, Young-Sam Keum, International Conference on Food Factors . 2000

机译：姜黄素和辣椒素对真核转录因子激活的抑制作用，NF - ## B和AP-1
5. Ric-8A Deletion and Phorbol Ester Suppresses Tumorigenesis in a Mouse Model of GNAQQ209L -driven Melanoma. [D] . Patel, Bharti. 2016

机译：Ric-8A删除和Phorbol酯抑制GNAQQ209L驱动的黑色素瘤小鼠模型中的肿瘤发生。
6. Effects of phorbol ester on contraction intracellular pH and intracellular Ca2+ in isolated mammalian ventricular myocytes. [O] . K T MacLeod, S E Harding 1991

机译：佛波酯对分离的哺乳动物心室肌细胞收缩细胞内pH和细胞内Ca2 +的影响。
7. Dose-response Effects of Phorbol Esters Isolated from Jatropha Meal on Rumen Microbial Activities [O] . Ehsan Oskoueian, Norhani Abdullah, Wan Zuhainis Saad, 2013

机译：麻风蛋白蛋白质蛋白蛋白酶对瘤胃微生物活性的剂量 - 反应作用
8. Interactive Effects of Aldrin, Cyclohexylamine, 2,4-Diaminotoluene and Two Phorbol Esters on Metabolic Cooperation between V79 Cells [R] . Mills, L. J., Robson, D. L., Malcolm, A. R. 1991

机译：aldrin，环己胺，2,4-二氨基甲苯和两种佛波酯对V79细胞代谢协同作用的交互作用

Phorbol esters with Wnt signal-augmenting effects isolated from Excoecaria indica

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