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首页> 外文期刊>Biochemistry >Influence of cis-[Re_2GABA_2Cl_4]Cl_2 on the Antioxidant Defense System Parameters of Normal Human Blood
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Influence of cis-[Re_2GABA_2Cl_4]Cl_2 on the Antioxidant Defense System Parameters of Normal Human Blood

机译:顺式[Re_2GABA_2Cl_4] Cl_2对正常人血液抗氧化防御系统参数的影响

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摘要

The effect of the rhenium complex cis-[Re_2GABA_2Cl_4]Cl_2 on the antioxidant parameters of normal human blood in vitro have been studied. The results suggest that the complex influences various enzymes in the cascade of reactions utilizing active oxygen metabolites. However, the manifestation of this activity varies over the studied concentration range of the complex in the precincubation medium (10~(-12)-10~(-4) M), so the effects appear to be concentration-dependent. The largest differences in antioxidant parameters in comparison with control were observed for the concentrations 10~(-8) 10~(-5), and 10~(-4) M. Thus, correslations between the peroxidation level, superoxide dismutase (SOD) activity, antioxidant factor (F), and indexes of resistance of erythrocytes for hemolysis (TR) were found.
机译:研究了complex络合物顺式[[Re_2GABA_2Cl_4] Cl_2]对正常人血液体外抗氧化参数的影响。结果表明,该复合物会影响利用活性氧代谢产物的级联反应中的各种酶。然而,这种活性的表现在预培养培养基中所研究的复合物的浓度范围(10〜(-12)-10〜(-4)M)上有所不同,因此效果似乎与浓度有关。在浓度为10〜(-8),10〜(-5)和10〜(-4)M的情况下,抗氧化剂参数与对照相比差异最大。因此,过氧化水平与超氧化物歧化酶(SOD)之间存在相关性发现了其活性,抗氧化剂因子(F)和红细胞的溶血抵抗性指数(TR)。

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