Pituitary tumors: predicting glucose metabolism after surgery for acromegaly.

摘要

A preoperative insulinogenic index >0.5 could predict restoration of normal glucose metabolism in Japanese patients after surgical cure of acromegaly, report researchers from Tokyo.Acromegaly is often associated with impaired glucose metabolism. Normalization of this metabolic defect may occur after acromegaly is cured; however, predicting which patients will respond has proven difficult. "In clinical practice, we were experiencing that impaired glucose metabolism was gone in some patients but not in others, even after cure of acromegaly," senior author Yasuhiro Takeuchi explains. "We wondered how we could tell our patients with acromegaly coincident with diabetes mellitus whether or not they would be free from both diseases after successful pituitary surgery."