Gynecological cancer: Endometriosis link to invasive subtypes

摘要

Previous studies have shown an association between endometriosis and increased risk of invasive epithelial ovarian cancer; however, "the risk associated with endometriosis might vary according to the [histological] subtype," according to a new study by Pearce et al. published in Lancet Oncology.In a pooled anlysis of 13 case-controlled studies from the Ovarian Cancer Association Consortium database, the investigators assessed self-reported endometriosis data from a total of 23,144 women-13,326 controls, 7,911 with invasive ovarian cancer and 1,907 with borderline ovarian cancer. When stratified by age (5-year categories) and ethnic origin (non-Hispanic white, Hispanic white, black, Asian, and other), and adjusted for duration of oral contraceptive use (ranging from 0 to > 10 years), self-reported history of endometriosis was associated with a significantly increased risk of invasive clear-cell, invasive low-grade serous and invasive endometrioid ovarian cancer subtypes.