Infection: High-throughput drug screen strikes gold in the search for a new amoebiasis treatment

摘要

Auranofin-an FDA-approved gold-containing drug used as a rheumatoid arthritis treatment for 25 years-could be a promising new therapy for amoebiasis, A coEaboration led by Sharon Reed and James McKerrow overcame the challenge of working with the slow-growing anaerobic parasite Entamoeba histolytica to develop an automated high-throughput assay capable of screening large, diverse inhibitor libraries for amoebicidal activity.