Metabolism: Age-dependent balance of leptin and ghrelin regulates bone metabolism

摘要

Ghrelin and leptin can promote and suppress osteoclastogenesis. These hormones interact to control bone metabolism and their relationship changes with age, according to a new study published in Endocrinology."We found that ghrelin regulates osteoclastogenesis and that leptin and ghrelin control bone metabolism through an interaction that changes with age," explains senior author Hans van Leeuwen from Erasmus University Medical Centre in Rotterdam, The Netherlands.