Gut microbiota: Not so sweet - Artificial sweeteners can cause glucose intolerance by affecting the gut microbiota

摘要

The effect of NAS in humans was then examined. The researchers used data from an ongoing clinical nutritional study, including information on the consumption of NAS and clinical parameters of 381 participants who did not have diabetes mellitus. Consumption of NAS was positively associated with several parameters related to the metabolic syndrome, including increased weight and fasting blood levels of glucose. Similarly to the findings in mice, 16S ribosomal RNA gene sequencing showed that participants who consumed NAS had a different microbiota composition compared with those who did not consume NAS, independently of BMI.