Cardiovascular endocrinology: Controversy - Cardiovascular effects of calcium supplementation

摘要

The issue of the cardiovascular safety of calcium supplements has now been revisited by Lewis and colleagues in a further meta-analysis.7 "Current evidence does not support the hypothesis that calcium supplementation with or without vitamin D increases coronary heart disease" the authors conclude. Readers of this report7 are likely to be puzzled as to why the authors reached such different conclusions from previous meta-analyses,4'6 as the new report does not explore the reasons for this difference. A number of differences in the approach taken by Lewis and co-workers7 account for the apparently different outcomes reported.