GASTROINTESTINAL HORMONES Uroguanylin-a new gut-derived weapon against obesity?

摘要

A recent report has identified uroguanylin as an endocrine signal that exerts a physiological role in energy homeostasis, adding another factor to the gut-brain axis. From a clinical point of view, several observations highlight the uroguanylin-guanylyl cyclase C pathway as a potential therapeutic target for the development of antiobesity drugs.