FOXM1 and CENPF: co-pilots driving prostate cancer

摘要

Using an integrative computational approach, Aytes et al. have shown that forkhead box Ml (F0XM1) and centromere protein F (CENPF) act synergistically to drive aggressive prostate cancer.Prostate tumours are highly heterogeneous and have relatively few recurrent gene mutations, which renders molecular subtyping and the identification of driver mutations difficult. Genetically engineered mouse models (GEMMs) of prostate cancer have proven to be useful in modelling prostate cancer-associated genes and pathways, but the extrapolation of these data to humans is hindered by inherent differences between species.