Neurodegenerative disease: The stress of misfolding.

摘要

The build-up of misfolded a-synuclein is linked to neurodegen-eration in Parkinsons disease and other so-called a-synucleinopathies, but how a-synuclein triggers neuronal death in vivo is unclear. Together, two studies from Lee and colleagues show that endoplasmic reticulum (ER) stress contributes to a-synuclein-linkedneurodegenera-tion in mice, and that oligomeric species of a-synuclein may have a role in the induction of such stress.