Neural development: Neurogenesis ends near the beginning.

摘要

In rodent mammals, substantial numbers of new neurons that are destined for the olfactory bulb are produced in the subventricular zone (SVZ), but whether this occurs in adult humans remains controversial. Sanai et al. now show that in humans, robust neurogenesis is present in neonatal infants, with streams of neural progenitors migrating both rostrally, and medially to the prefrontal cortex. Crucially, however, they find that this neurogenesis declines sharply during childhood and is virtually absent by adulthood.