The roles of placental growth factor (PLGF; also known as PGF) in tumour growth and angiogenesis have been intensely debated. Rakesh Jain and colleagues investigated the function of PLGF in medulloblastoma and found that, in these tumours, PLGF may signal through a non-tyrosine kinase receptor, neuropilin 1 (NRP1), to promote tumour cell survival-without having a substantial effect on tumour-associated macrophages or angiogenesis.
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