Epigenetics: Melanoma insights written in the DNA

摘要

Both groups also examined the activation of pathways downstream of ECFR. Ardito et a!, found that a threshold level of ERK activation, achieved by activation of both KRAS and EGFR, was required for PanIN formation. Navas etal. noted increased activation of the PI3K-AKT pathway and signal transducer and activator of transcription 3 (STAT3). Futher studies should determine the relevance of these pathways to human PDA progression.