Oncogenic morphs of p53.

摘要

Do these histone mutations alter transcription? Interestingly, despite K27- and G34-mutant tumours being histologicaly indistinguishable, gene expression microarray analyses revealed distinct transcriptional programmes between these two mutant types. This result also indicates that these mutations have pleiotropic effects on gene expression, as might be expected from disruptions to chromatin. However, whether any tumour-promoting effects of these mutations involve the deregulated expression of a few or many cancer genes is currently unknown.