Cancer genomics: Coming in waves

摘要

One benefit of large-scale cancer genome-sequencing projects is that they are poised to give us insights into temporal alterations in cancer genomes and thus into how these alterations contribute to tumour initiation and progression. In order to better understand the genomic architecture and evolution of prostate cancer, Levi Garraway, Francesca Demichelis and colleagues conducted whole-genome sequencing of 57 prostate tumours and matched normal tissue, and they used computer modelling to analyse how genomic rearrangements arise.