THE REACTIVITY OF 8-HYDROXYQUINOLINE AND ITS DERIVATIVES TOWARD α-CYANOCINNAMONITRILES AND ETHYL α-CYANOCINNAMATES: SYNTHESIS, REACTIONS, AND APPLICATIONS OF 4H-PYRANO3,2-hQUINOLINE DERIVATIVES

摘要

The main purpose of this review is to present a literature survey on the reactivity of 8-hydroxyquinoline and its derivatives toward α-cyanocinnamonitrile or ethyl α-cyanocinnamate derivatives, which leads to the formation of a variety of 4H-pyrano3,2-hquinoline derivatives. The reactions of the synthesized β-enaminonitriles and β-enaminoesters with different electrophilic followed by nucleophilic reagents were also explored. Some of these reactions provided successful routes to produce biologically important privileged structures.