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外文期刊>Molecular genetics and metabolism
>To the knowledge of the 20GYGFG 24 sequence stretch of type-1 VDAC: To understand why BCl-XL B4 domain peptides keep HeLa cells closed in hypotonic surroundings
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To the knowledge of the 20GYGFG 24 sequence stretch of type-1 VDAC: To understand why BCl-XL B4 domain peptides keep HeLa cells closed in hypotonic surroundings
Type-1 VDAC/porin, as a part of its voltage sensor, includes a GxxxG motif sequence that has been shown to work as an ATP-binding site. The motif has also been demonstrated to function as an aggregation/membrane perturbation sequence that opens VDAC in the plasmalemma of neuronal cells in experiment on apoptosis induction. Here it is discussed how type-1 VDAC channels at the cell surface of HeLa cells in hypotonic surroundings might be kept closed after pre-incubation with BCl-XL B4 domain peptides.
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