Large cell neuroendocrine carcinoma of the nasopharynx: A case report [Tumeur neuroendocrine à grandes cellules du nasopharynx: à propos d'un cas]

摘要

Neuroendocrine carcinoma of the head and neck is a rare entity. The parotid gland is the most commonly affected site. A nasopharyngeal site has not been previously described. We report a 35-year-old patient who consulted for tinnitus and nasal obstruction. The assessment found a nasopharyngeal tumour T4N0M0. The patient underwent 6cycles of chemotherapy based on VP16and cisplatin, followed by radiotherapy at a dose of 70. Gy to the nasopharynx and 50. Gy to the neck. The evolution was marked by clinical improvement and radiological stability. Six months after the end of treatment, the patient had a local and meningeal relapse. He received palliative care. He died 19months after the end of treatment.