Evaluation of 122 advanced-stage cutaneous squamous cell carcinomas by comprehensive genomic profiling opens the door for new routes to targeted therapies

Al-Rohil Rami N.; Tarasen Ashley J.; Carlson J. Andrew; Wang Kai; Johnson Adrienne; Yelensky Roman; Lipson Doron; Elvin Julia A.; Vergilio Jo-Anne; Ali Siraj M.; Suh James; Miller Vincent A.; Stephens Philip J.; Ganesan Prasanth; Janku Filip; Karp Daniel D.; Subbiah Vivek; Mihm Martin C.; Ross Jeffrey S.

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Evaluation of 122 advanced-stage cutaneous squamous cell carcinomas by comprehensive genomic profiling opens the door for new routes to targeted therapies

机译：通过全面的基因组分析对122种晚期皮肤鳞状细胞癌进行评估，为靶向治疗的新途径打开了大门

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BACKGROUNDThe authors hypothesized that comprehensive genomic profiling of advanced-stage cutaneous squamous cell carcinoma (cSCC) could identify genomic-derived drug targets of therapy for patients with conventional therapy-resistant disease.

机译：背景作者推测，高级皮肤鳞状细胞癌（cSCC）的全面基因组图谱分析可以确定传统治疗耐药性疾病患者的基因组药物治疗靶标。

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《Cancer: A Journal of the American Cancer Society》 |2016年第2期|共9页
作者
Al-Rohil Rami N.; Tarasen Ashley J.; Carlson J. Andrew; Wang Kai; Johnson Adrienne; Yelensky Roman; Lipson Doron; Elvin Julia A.; Vergilio Jo-Anne; Ali Siraj M.; Suh James; Miller Vincent A.; Stephens Philip J.; Ganesan Prasanth; Janku Filip; Karp Daniel D.; Subbiah Vivek; Mihm Martin C.; Ross Jeffrey S.;
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正文语种 eng
中图分类肿瘤学;
关键词
cutaneous squamous cell carcinoma; genomic alterations; genomic profiling; next-generation sequencing;

机译：皮肤鳞状细胞癌;基因组改变;基因组概况分析;下一代测序;

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1. Evaluation of 122 advanced-stage cutaneous squamous cell carcinomas by comprehensive genomic profiling opens the door for new routes to targeted therapies [J] . Al-Rohil Rami N., Tarasen Ashley J., Carlson J. Andrew, Cancer: A Journal of the American Cancer Society . 2016,第2期

机译：通过全面的基因组分析对122种晚期皮肤鳞状细胞癌进行评估，为靶向治疗的新途径打开了大门
2. Prospective Comprehensive Genomic Profiling of Advanced Gastric Carcinoma Cases Reveals Frequent Clinically Relevant Genomic Alterations and New Routes for Targeted Therapies [J] . Ali Siraj M., Sanford Eric M., Klempner Samuel J., The oncologist . 2015,第5期

机译：晚期胃癌病例的前瞻性综合基因组分析揭示了临床上常见的基因组改变和靶向治疗的新途径
3. Prospective Comprehensive Genomic Profiling of Advanced Gastric Carcinoma Cases Reveals Frequent Clinically Relevant Genomic Alterations and New Routes for Targeted Therapies [J] . Siraj M. Ali, Eric M. Sanford, Samuel J. Klempner, The oncologist . 2015,第5期

机译：晚期胃癌病例的前瞻性综合基因组分析揭示了临床上常见的基因组改变和靶向治疗的新途径
4. Treating cutaneous squamous cell carcinoma using ALA PLGA nanoparticle-mediated photodynamic therapy in a mouse model [C] . Xiaojie Wang, Lei Shi, Qingfeng Tu, Biophotonics and immune responses X . 2015

机译：使用ALA PLGA纳米粒子介导的光动力疗法在小鼠模型中治疗皮肤鳞状细胞癌
5. Regulation and targeting of Fyn in human cutaneous squamous cell carcinoma. [D] . Fenton, Sarah E. 2014

机译：Fyn在人皮肤鳞状细胞癌中的调控和靶向作用。
6. Prospective Comprehensive Genomic Profiling of Advanced Gastric Carcinoma Cases Reveals Frequent Clinically Relevant Genomic Alterations and New Routes for Targeted Therapies [O] . Siraj M. Ali, Eric M. Sanford, Samuel J. Klempner, 2015

机译：晚期胃癌病例的前瞻性综合基因组分析揭示了临床上常见的基因组改变和靶向治疗的新途径
7. Prospective Comprehensive Genomic Profiling of Advanced Gastric Carcinoma Cases Reveals Frequent Clinically Relevant Genomic Alterations and New Routes for Targeted Therapies [O] . Siraj M. Ali, Eric M. Sanford, Samuel J. Klempner, 2015

机译：晚期胃癌病例的前瞻性综合基因组分析揭示了临床相关的基因组改变和针对有针对性疗法的新途径

Evaluation of 122 advanced-stage cutaneous squamous cell carcinomas by comprehensive genomic profiling opens the door for new routes to targeted therapies

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