Slippage and self-seating of the knots under load is unavoidable even with highest tying loads. Relatively minor but possibly important differences can be seen for tying loads exceeding 2 N (Vicryl) and 10 N (PDS and FibreWire) for failure load and knot slippage. But also with a tying load of 50 N, a minimal slippage of approximately 3 mm seems unavoidable for all suture types. However, it is important to state that intense tightening does not prevent knot resolution and is only necessary in clinical situations that demand very tight sutures. Numbers and proper appliance of throws are more relevant than tying strength to reach the maximum failure load.
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