Clinical Next-Generation Sequencing in Patients with Non-Small Cell Lung Cancer

Hagemann Ian S.; Devarakonda Siddhartha; Lockwood Christina M.; Spencer David H.; Guebert Kalin; Bredemeyer Andrew J.; Al-Kateb Hussam; Nguyen TuDung T.; Duncavage Eric J.; Cottrell Catherine E.; Kulkarni Shashikant; Nagarajan Rakesh; Seibert Karen; Baggstrom Maria; Waqar Saiama N.; Pfeifer John D.; Morgensztern Daniel; Govindan Ramaswamy

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Clinical Next-Generation Sequencing in Patients with Non-Small Cell Lung Cancer

机译：非小细胞肺癌患者的临床下一代测序

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摘要

BACKGROUNDA clinical assay was implemented to perform next-generation sequencing (NGS) of genes commonly mutated in multiple cancer types. This report describes the feasibility and diagnostic yield of this assay in 381 consecutive patients with non-small cell lung cancer (NSCLC).

机译：背景技术实施临床测定法以执行通常在多种癌症类型中突变的基因的下一代测序（NGS）。该报告描述了该测定在连续381例非小细胞肺癌（NSCLC）患者中的可行性和诊断价值。

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《Cancer: A Journal of the American Cancer Society》 |2015年第4期|共9页
作者
Hagemann Ian S.; Devarakonda Siddhartha; Lockwood Christina M.; Spencer David H.; Guebert Kalin; Bredemeyer Andrew J.; Al-Kateb Hussam; Nguyen TuDung T.; Duncavage Eric J.; Cottrell Catherine E.; Kulkarni Shashikant; Nagarajan Rakesh; Seibert Karen; Baggstrom Maria; Waqar Saiama N.; Pfeifer John D.; Morgensztern Daniel; Govindan Ramaswamy;
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正文语种 eng
中图分类肿瘤学;
关键词
biomarkers; high-throughput nucleotide sequencing; molecular targeted therapy; neoplasms; non-small cell lung cancer; personalized medicine;

机译：生物标志物;高通量核苷酸测序;分子靶向治疗;肿瘤;非小细胞肺癌;个性化医学;

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1. 吉非替尼治疗局部晚期或转移性非小细胞肺癌患者疗效及生存的临床预测因素——两项Ⅱ期临床研究的综合分析 [J] . 赵媛媛, 张阳, 赵洪云, 癌症（英文版） . 2009,第006期
2. The utilization of next-generation sequencing to detect somatic mutations and predict clinical prognosis of Chinese non-small cell lung cancer patients [J] . Liming Cao, Long Long, Min Li, OncoTargets and therapy . 2018,第2期

机译：下一代测序的利用检测体细胞突变并预测中国非小细胞肺癌患者的临床预后
3. Assessment of the clinical application of detecting EGFR, KRAS, PIK3CA and BRAF mutations in patients with non-small cell lung cancer using next-generation sequencing [J] . Xu Xinnan, Yang Yang, Li Hui, Scandinavian journal of clinical and laboratory investigation. . 2016,第1a8期

机译：下一代测序技术检测非小细胞肺癌患者EGFR，KRAS，PIK3CA和BRAF突变的临床应用评估
4. Clinical Next-Generation Sequencing in Patients with Non-Small Cell Lung Cancer [J] . Hagemann Ian S., Devarakonda Siddhartha, Lockwood Christina M., Cancer: A Journal of the American Cancer Society . 2015,第4期

机译：非小细胞肺癌患者的临床下一代测序
5. The clinical efficacy of transfusion of cytokine-induced killer cells combined with chemotherapy and XiaoJi decoction in patients with stage IIIB/IV non-small cell lung cancer [C] . Liuning Li, Jiaying Liu, Xiaoshu Chai, IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：细胞因子诱导的杀伤细胞输注结合化学疗法和消积汤治疗IIIB / IV期非小细胞肺癌的临床疗效
6. The cost effectiveness of screening for early stage lung cancer and the testing and treatment of molecular subgroups among non-small cell lung cancer patients in the province of ontario, canada [D] . Thao, Mallory. 2014

机译：加拿大安大略省非小细胞肺癌患者早期肺癌筛查的成本效益及分子亚群的检测和治疗
7. The utilization of next-generation sequencing to detect somatic mutations and predict clinical prognosis of Chinese non-small cell lung cancer patients [O] . Liming Cao, Long Long, Min Li, 2018

机译：利用下一代测序技术检测中国非小细胞肺癌患者的体细胞突变并预测临床预后
8. The utilization of next-generation sequencing to detect somatic mutations and predict clinical prognosis of Chinese non-small cell lung cancer patients [O] . Liming Cao, Long Long, Min Li, 2018

机译：下一代测序的利用检测体细胞突变并预测中国非小细胞肺癌患者的临床预后

Clinical Next-Generation Sequencing in Patients with Non-Small Cell Lung Cancer

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