p53 Condon 72 Polymorphism as a Risk Factor in the Development of Breast Cancer

摘要

The p53 gene is polymorphic at amino acid 72 of : the protein that it encodes. It has been reported that 1 patients with the arginine form have a higher risk of J developing other forms of cancer than those with the 1 proline form. The purpose of this study was to exam- I ine whether p53 Arg at the polymorphic position 72 could represent a risk factor for women with breast lesions. The study population included 56 biopsies from patients with breast lesions. Also, 61 normal blood samples were used as controls. There was a difference in the distribution of p53 genotypes be- tween breast cancer lesions and the normal samples. The allele frequency of p53 Arg/Arg was much higher than that of the normal samples (61% versus 20%). Based on the findings of this study, it is suggested that p53 Arg homozygosity could represent a risk factor for the tumorigenesis of the breast.