Sleep apnea associated with floppy epiglottis in adult-onset Alexander disease: a case report.

摘要

Alexander disease is a rare leukoencephalopathy, caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP). A recent study reported that patients with adult-onset Alexander disease might develop sleep-disordered breathing (SDB), a condition characterized by repeated episodes of apnea and hypopnea during sleep,although the mechanism of airway obstruction in this disease has not been clarified. Here we report a patient with adult-onset Alexander disease presenting with SDB associated with floppy epiglottis.