Increased Risk of Mortality following Antibiotic Treatment in Patients with Coronary Artery Disease?

摘要

Chronic infections as potential pathogenic factors in atherothrombotic vascular diseases have attracted increased attention due to evidence indicating a critical role of inflammation in the evolution and progression of atherothrombosis.Several bacterial infections have been implicated in the progression of atherothrombosis. These include Chlamydia pneumoniae, Helicobacter pylori and Porphyromonas gingivalis. While initial small clinical studies suggested a reduction in clinical events and inflammatory markers following the administration of antibiotics to eradicate these pathogens, larger studies in patients with chronic coronary artery disease and after acute coronary syndrome have been negative.