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Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing

机译:使用增强的连续流工艺胺化卤代芳烃和酯

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摘要

Significant process intensification of the amination reactions of aryl halides and esters has been demonstrated using continuous flow processing. Using this technology traditionally difficult amination reactions have been performed safely at elevated temperatures. These reactions were successfully conducted on laboratory scale coil reactor modules with 1 mm internal diameter (ID) and on a preparatory scale tubular reactor with 6 mm ID containing static mixers.
机译:使用连续流工艺已证明芳基卤化物和酯的胺化反应的显着工艺增强。传统上,使用该技术已经在高温下安全地进行了困难的胺化反应。这些反应在具有1 mm内径(ID)的实验室规模的盘管反应器模块上以及在具有6 mm ID的静态混合器的制备规模的管式反应器上成功进行。

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