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Six New Triterpene Derivatives from Aralia chinensis Var. dasyphylloides

机译:中华五加木的六种新的三萜衍生物菊科植物

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Aralia chinensis var. dasyphylloides is widely distributed in China and used as a traditional herbal medicine for the treatment of digestive and immune system diseases. The present study aimed to search for novel oleanolic-type triterpenoids in low-polarity fractions. Six new triterpene derivatives (1-6), together with two known compounds were isolated from the barks of A. chinensis var. dasyphylloides. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analysis and chemical methods. They were identified as 3-oxo-oleana-11,13(18)-dien-28,30-dioic acid (1), 30-hydroxy-3-oxo-oleana-11,13(18)-dien-28-oic acid (2), 3 beta-hydroxy-oleana-11,13(18)-dien-28-oic acid-28-O-beta-D-glucopyranoside (3), 3 beta,30-dihydroxy-oleana-11,13(18)-dien-28-oic acid-28-O-beta-D-glucopyranoside (4), 3 beta-hydroxy-oleana-11,13(18)-dien-28-oic acid-3-O-beta-D-xylopyranosyl-(1 -> 2)-beta-Dglucopyranoside (5), 3 beta,29-dihydroxy-oleana-9(11), 12-dien-28-oic acid-28-O-beta-D-glucopyranoside (6), namely, araliachinolic acids I and II and araliachinosides I-IV. The cytotoxicity of the isolated compounds was tested against HepG2, A549, SGC7901, and MCF7 cell lines, but no apparent activity was observed at a concentration of 50 mu M.
机译:中华菊苣在中国分布广泛,被用作治疗消化系统和免疫系统疾病的传统草药。本研究旨在寻找低极性馏分中的新型齐墩果型三萜。从中华曲霉的树皮中分离出六个新的三萜衍生物(1-6),以及两个已知的化合物。菊科植物。通过1D和2D-NMR光谱分析和化学方法阐明了它们的结构。他们被确定为3-oxo-oleana-11,13(18)-dien-28,30-diic acid(1),30-hydroxy-3-oxo-oleana-11,13(18)-dien-28-油酸(2),3 beta-hydroxy-oleana-11,13(18)-dien-28-oic acid-28-O-beta-D-glucopyranoside(3),3 beta,30-dihydroxy-oleana-11 ,13(18)-dien-28-oicacid-28-O-β-D-吡喃葡萄糖苷(4),3 beta-hydroxy-oleana-11,13(18)-dien-28-oic acid-3-O -β-D-吡喃喃糖基-(1-> 2)-β-D-吡喃葡萄糖苷(5),3个β,29-二羟基-油酸9(11),12-二烯-28-油酸-28-O-β- D-吡喃葡萄糖苷(6),即花生四烯酸I和II以及花生四烯苷I-IV。测试了分离的化合物对HepG2,A549,SGC7901和MCF7细胞系的细胞毒性,但在50μM的浓度下未观察到明显的活性。

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