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Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model

机译:查尔酮和查尔酮类似物在斑马鱼模型中的抗炎作用评价

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摘要

The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.
机译:本研究的目的是研究在体内具有有效抗炎活性的新型查耳酮。使用尾鳍缠绕的转基因斑马鱼品系“ Tg(mpx:gfp)”对查尔酮和两个查尔酮类似物(化合物5和9)进行了评估,以动态观察中性粒细胞募集的效果。结果表明,用化合物9处理不仅影响伤口诱导的嗜中性白细胞募集,而且还影响Mpx的酶活性。而且,促炎因子(Mpx,NFκB和TNFα)的蛋白表达水平也受化合物9的调节。总的来说,我们的结果提供了体内合成查尔酮类似物对伤口诱导的炎症的抗炎作用的证据。

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