miR-590-3p Is a Novel MicroRNA in Myocarditis by Targeting Nuclear Factor Kappa-B in vivo

摘要

Acute myocarditis is a proinflammatory disease in myocardial tissue [1], Up to now, a broad array of etiologies, such as multiple immune, autoimmune and viral infections, have been proposed, but only a few mechanisms have been clarified [2,3]. Many studies have demonstrated that nuclear factor kappa-B (NF-kB)-induced proin-flammation may play an important role in the development of this disease [4,5], during which many proinflammatory cytokines such as interleukin-6 (IL-6) and monocyte chemotactic protein-1 (MCP-1) are released, and the direct result is necrosis of myocytes.