Electrochemical characterization of micro- and nano-particles of ceftriaxone in human blood serum samples using cyclic voltammetry

摘要

The present study has selected one important antibiotic compound in a microcrystalline of ceftriaxone (CRX) and then it was converted into nano-particles (NPs) by lyophilization (freeze-drying method). The CRX NPs was characterized by electrochemical analysis using cyclic voltammetric method by glassy carbon electrode (GCE) in human blood serum medium. It was found that CRX has oxidation-reduction current peaks at 0.9 and -0.75 V respectively, while the cyclic voltammogram of CRX NPs was illustrated the reduction current peak at -0.75 V and the oxidation peak cannot be seen, so this phenomena explains that CRX NPs act as antioxidant antibiotic in serum medium. Also, the study included the electrochemical behavior of nano antibiotic CRX NPs in different pH and concentration. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) was applied.