On-Line Analytical Techniques for Monitoring Crystallisation Processes of Organic Speciality Chemicals

摘要

In order to examine on-line batch crystallisation processes a new integrated batch process engineering laboratory has been established providing facilities for the on-line measurement and control of:· reactant supersaturation via ATR-FTIR spectroscopy;· crystal size via acoustic attenuation spectroscopy:· particle perfection and polymorphic form via X-ray diffraction;· crystallisation on-set and meta-stable zone width via UV vis spectroscopic turbidometric measurements.These facilities are complemented via assessment of reactant mixing as measured via laser doppler anemometry and simulated using multi-phase computational fluid dynamics. An overview of the planned research programme and material systems to be examined are presented: